FACTOR 12: OPTI-CILLIN
Herbal Antibiotic, Antiviral, and Antifungal Formulation

WHO SHOULD USE (LIFESTYLE)

purpdot.gif (897 bytes)Individuals suffering from seasonal chronic colds or flu.
purpdot.gif (897 bytes)Patients susceptible to bronchitis, pneumonia, and/or sinus problems.
purpdot.gif (897 bytes)Women experiencing recurrent cystitis.
purpdot.gif (897 bytes)Children and adults experiencing ear aches.
purpdot.gif (897 bytes)Individuals exhibiting chronic fungal skin infections.
purpdot.gif (897 bytes)Persons who travel and /or dine out extensively.
purpdot.gif (897 bytes)Individuals with herpes simplex Type 1 or 2

REASONS TO USE (AILMENTS)

purpdot.gif (897 bytes)Upon experiencing first symptoms of upper respiratory congestion, chronic cough or onset of fever, cold or flu. (Recommended in combination with Factor One for best results. Consult "Holistic Recommendations" this report).
purpdot.gif (897 bytes)Onset of bladder and urinary tract infection. (Recommended in combination with Factor Eleven for best results.
purpdot.gif (897 bytes)Upon first symptoms of ear ache or external otitis (swimmer's ear).
purpdot.gif (897 bytes)Onset of recurrent yeast infection, skin rashes, or severe itching from exposure to parasites or poisonous plants.
purpdot.gif (897 bytes)Onset of suspected food poisoning (chronic stomach ache, cramps, diarrhea), especially following foreign travel.
purpdot.gif (897 bytes)Immediately upon onset of cold sore and/or genital blisters.


DOSAGE & DIRECTIONS

At first signs of infection, flu, congestion, bronchial, or fungal symptoms, take 3 capsules twice daily for 10 days for maximum therapeutic benefit. Do not discontinue before vial has been depleted. May be taken with or without food.

CONTRAINDICATIONS & PRECAUTIONS

This formulation is safe for both children and the elderly. There is no known toxicity or contraindications with this product when taken in the recommended dosage. However, do not take during pregnancy. As with all dietary supplements, do not take at the same time as medications.

FACTOR TWELVE FORMULATION
Two Capsules Equal:

Camellia sinensis extract (50% polyphenol content)
Berberis alkaloid extract equal to
Echinacea (angustifolia) extract equal to
Panax Ginseng root extract (5% ginsenosides) equal to
Usnea (Usnea barbata)
Ocimum basilicum
Rosmarinus officinalis
Garlic extract (from 66 mg fresh garlic)
Chorophylllin (pure)
360 mg
275 mg
250 mg
200 mg
100 mg
100 mg
35 mg
4 mg
1 mg

VALIDATION OF INGREDIENTS

CAMELLIA SINENSIS (GREEN TEA) EXTRACT (50% polyphenol content) contains potent antioxidant compounds that have demonstrated greater antioxidant protection than vitamins C and E in experimental studies as well as exhibit anti-allergy activity.1,2 Green tea extract is also rich in Theophylline, a compound used as a prescription drug in the treatment of asthma.3

The polyphenols in camellia sinensis have also been shown to stimulate the production of several immune system cells, and have antibacterial properties - even against the bacteria that cause dental plaque.4,5,6 In fact, the polyphenols are believed to be responsible for most of green tea's role in promoting good health.7

Green tea polyphenols inhibit cancer by blocking the activation of carcinogens, and detoxifying or trapping cancer-causing compounds such as nitrosamines, suppressing the activation of carcinogens, and detoxifying or trapping cancer-causing agents. The forms of cancer that appear to be best prevented are cancers of the gastrointestinal tract, the stomach, small intestine, pancreas, colon, lung cancer, and estrogen-related cancers including most breast cancers8,9

Camellia sinensis guards against cardiovascular disease by lowering total cholesterol levels while improving the cholesterol profile of LDL to HDL cholesterol and lowering blood pressure.10,11

BERBERIS ALKALOID EXTRACT containing the major alkaloid, berberine, has been extensively studied in clinical settings. Berberine has shown antibiotic activity against bacteria, protozoa, and fungi, including Staphylococcus species, Streptomyces species, Corynebacterium diphtheria, E. coli, salmonella typhi, Diplococcus pneumoniae, Trichomonas vaginalis, N. meningitidis, and Candida albicans.12,13,14

Berberine has the ability to inhibit the adherence of streptococci to host cells. Simply stated, berberine interferes with infections due to streptococci not only by inhibiting streptococcal growth, but also by blocking these organisms to host cells.15

Berberine has been found effective against diarrheas caused by E. coli (traveler's diarrhea), Shigella dysenteriae (shigellosis), Salmonella paratyphi (food poisoning), and Vibrio cholerae (cholera). Clinical studies have produced results with berberine comparable to those of standard antibiotics in most cases, and in several studies results were actually superior.16,17,18

ECHINACEA (ANGUSTIFOLIA) EXTRACT activates a part of the immune system known as the alternate complement pathway. As a result, the movement of white blood cells into areas of infection is enhanced; immune complexes solubilize; and bacteria, viruses and other microorganisms are destroyed.19,20

Echinacea elevates serum white blood cell counts when they are low, including T lymphocytes, or T cells.21 These cells are a type of white blood cell responsible for "cell-mediated immunity" which refers to immune mechanisms not controlled or mediated by antibodies. This is extremely important in providing resistance to infection by mold-like bacteria, yeast, fungi, parasites, and viruses including those that cause hepatitis.22,23

Cell-mediated immunity is also critical in protecting against the development of cancer, autoimmune disorders such as rheumatoid arthritis, and allergies. Echinacea has been successfully utilized to treat all of these conditions.24

Echinacea extract stimulates stem cells in bone marrow and lymphatic tissue where immune system cells are produced, and increase the number and activity of these cells in the blood and lymphatic circulation.25

It has been stated that Echinacea is one of the most powerful and effective remedies against bacteria and viral infections.26

PANAX GINSENG ROOT EXTRACT (standardized to 5% ginsenosides) exerts numerous pharmacological effects including antistress activity, improved endocrine system function, enhanced protein synthesis and cell reproduction; improved glucose control in diabetics; lowering of serum cholesterol; and protection of the liver from toxic substances.27,28,29,30

Ginseng possesses immunostimulating activity as evidenced by its ability to enhance antibody responses, cell-mediated immunity and the production of interferon.31

Ginseng also has the ability to enhance the activity of the cells of the reticuloendothelial system. This system is composed of white blood cells known as macrophages, which filter the blood and lymph by engulfing and destroying bacteria, viruses, and other waste matter. Such macrophages are found in highest concentrations in the liver, spleen, and lymph nodes.32

The liver contains specialized macrophages known as Kupffer cells. Ginseng stimulates and increases the activity of these cells which are responsible for removing toxins and debris from the circulation.33 Ginseng has also been demonstrated to increase protein synthesis in the liver which is often reduced in the elderly.34

Clinical studies have shown that ingestion of ginseng by individuals with mild immune deficiency (frequent colds) may reduce the risk of viral infection.35

USNEA (BARBATA) contains usnic acid which acts as an antibiotic. Unlike other antibiotics which disrupt structural components of bacterial cells, usnea kills microbes by disrupting cellular metabolism. Also, unlike synthetic antibiotics which kill the natural flora in the vagina and gut, usnea does not kill "gram-postive" (friendly) bacteria and therefore does not adversely affect the body's natural ecology.36

Usnea has been found to be especially effective for acute bacterial infections. Many individuals have also had great success using usnea for sinusitis, bronchitis, pneumonia, and colds when nothing else had worked.37

OCIMUM BASILICUM exhibits in vitro antibacterial activity against Bacillus subtilis, E. coli, Pseudomonas auerginosa, and Staphylococcus aureus. Strong activity was also shown against Candida albicans.38

Ocimum basilicum is also a galactagogue and stomachic. It is useful for stomach cramps, gastric catarrh, vomiting and intestinal catarrh which are symptoms usually associated with colds, flu, and similar virus ailments.39

ROSMARINUS OFFICINALIS contains some of the most powerful candida killing substances available.40 The active constituents of this herb include eucalyptol which exhibits antibacterial effects41 and relaxes smooth muscles in the lungs.42 Rosmarinic acid has significant antioxidant activity.43

The stimulant action of rosemary helps promote liver function, the production of bile, and proper digestion. It also acts to improve circulation.44

GARLIC EXTRACT (from 66 mg fresh garlic) were found to be effective antibiotic agents against many bacteria, including Staphylococcus aureus, Escherichia coli, salmonella enteritidis, Klebsiella pneumoniae, and mycobacteria.45,46,47 These studies compared the antimicrobial effects of garlic with those of commonly used antibiotics, including penicillin, streptomycin, chloramphenicol, erythromycin, and tetracyclines. These studies demonstrated garlic's efficacy in inhibiting the growth of some bacteria that had become resistant to one or more of the antibiotics.

Garlic possesses important immune-enhancing and anticancer properties. Human studies show that garlic inhibits the formation of nitrosamines which are powerful cancer-causing compounds formed during digestion.48

Garlic has demonstrated significant antifungal activity against a wide range of fungi. Garlic is especially active against C. albicans, being more potent than Nystatin and six other reputed antifungal agents.49

Garlic's antiviral effects have been well studied. In vitro, fresh garlic killed herpes simplex types 1 and 2, para-influenza virus type 3, vesicular stomatitis virus, and human rhinovirus type 2. Fresh garlic extract was virucidal against all viruses tested but the virucidal activity of commercial products depended how they were prepared. Those products producing the highest level of allicin and other thio-sulfinates, such as found in Factor Twelve: Opti-cillin, had the best virucidal activity.50

Based on clinical research, the dosage of a commercial garlic product should provide a daily dose of 4 mg of allicin.51

CHLOROPHYLLIN (pure) is "natures deodorant" and aids in cleansing of the bloodstream.52 According to G. W. Rapp in the American Journal of Pharmacy, chlorophyllin also possesses positive antibacterial action and reduces the hazard of bacterial contamination. It's main purpose in this formulation, however, is to off-set some of the more pungent herbal extracts utilized in Factor Twelve: Opti-cillin.

HOLISTIC RECOMMENDATIONS

Common cold, Influenza, Bronchitis & Pneumonia. All of these conditions are infections of the upper respiratory tract caused by viruses which are impervious to synthetic antibiotics. The patient's immune system plays a large role in determining whether the body will fight off such infections.

Both the common cold and the "flu" are highly contagious because they can be spread easily by coughing and sneezing. Although both a cold or flu is rarely fatal by themselves, they do make the patient more susceptible to bronchitis, pneumonia, and sinus trouble.

The growing population of individuals with chronic lung diseases primarily due to smoking and immunosuppressive drugs has contributed to further increases of chronic bronchitis and serious pneumonias, which have very high mortality rates.53

It is most important therefore to boost the immune system to prevent the cold or flu from developing into something more significant. It will also reduce the severity and duration of the symptoms.

Exposure to a disease-causing microorganism does not always cause infections in the body and result in symptoms. The immune system plays a major role in determining whether the body will fight off infection.

Upon the very first sign of cold or flu symptoms (watery nasal discharge, sneezing, coughing, watery red eyes, general malaise) - or if individuals in close contact exhibit such signs - the patient should begin the recommended daily dosage of Factor Twelve:Opti-cillin and continue for the full ten day period until the entire vial has been depleted. This will assist the immune system in destroying such viruses and clear the infection before the on-set of disease.

Studies have linked malnutrition to viruses. Scientists have recently found the first direct evidence that viruses can mutate and become deadly because of nutritional deficiencies in the hosts they infect.54 If the nutritional status of the infected person proves to affect other disease-causing viruses it may turn out to be a factor in the evolution of more deadly forms of influenza, hepatitis and meningitis.55

It is recommended that Factor One: Bio-Immunizer be in-corporated into the patient's nutrition program during viral exposure. Patients with a compromised or depressed immune system subject to chronic colds and upper respiratory infec-tions should consider taking Factor One: Bio-Immunizer as a preventative on a consistent basis.

If the patient is experiencing an advanced stage of a cold or flu attack, Factor Nine: Respira-D may be incorporated into the natural antibiotic regime noting precautions.

Bladder and Urinary Tract Infection Bladder and urinary infections are usually caused by E. coli bacteria resulting in cystitis, an inflammation of the bladder.

Twenty-one percent of women have urinary infections at least once a year which may be uncomfortable or extremely painful and thirty-seven percent of women with no history of urinary infection will have one within 10 years.56

Symptoms are characterized by an urgent desire to empty the bladder. Urination is typically frequent and painful, such as a burning sensation and the urine may appear cloudy.

Recent clinical data suggests that ampicillin, trimethoprim, and trimetho-sulfamethoxazole, now used as first line treat-ment of acute cystitis, may not be acceptable choices for therapy much longer.57

It is imperative that patients experiencing the first signs of a urinary tract infection begin dosing with Factor Twelve: Opti-cillin and immediately incorporate Factor Eleven: CranPlex into their daily supplement regime.

Ear Infections, There are three types of earache:

1) External otitis (swimmer's ear) is an infection of the external ear canal with itching, discharge or burning pain;

2) Acute otitis media (also known as bacterial otitis media) is an infection of the middle ear and usually preceded by an upper respiratory infection or allergy; and

3) Chronic otitis media (also known as serious otitis media) refers to a constant swelling of the middle ear.

A number of studies have confirmed that there are no significant differences in the clinical course of acute otitis media when conventional treatments are compared with placebos except that children not receiving antibiotics had fewer recurrences than those who did receive antibiotics.58

In fact, subsequent studies revealed that children with chronic otitis media who took amoxicillin experienced 2 to 6 times more recurrent ear infections as compared to those on placebo.59

Upon the first signs of ear infection, the patient should begin the recommended daily dosage of Factor Twelve: Opti-cillin and continue for the full ten day cycle until the entire vial has been depleted.

For prevention of reoccurring ear infections, the vast majority of patients with recurrent ear infections improved after removing food allergens from their diets.60

Fungal Skin Infections

Candida albicans is the most common form of yeast-like fungus. When it infects the oral cavity, it is called thrush. When it infects the vagina, it results in vaginitis. Athlete's foot, ringworm and jock itch also develop as a result of a fungal infection. Moist red patches anywhere on the body often indicate an infection by fungal or, in some cases, staph bacteria.

A depressed immune function is a leading cause of most fungal infections. At the on-set of a fungal infection begin dosing with Factor Twelve: Opti-cillin for the full 10 day cycle and consider using Factor One: Bio-Immunizer as a preventative. (Women should consider Factor Ten: Femtrac)

Food Poisoning and 'Traveler's Diarrhea'

Food poisoning occurs when a person consumes food containing harmful bacteria. Each year more than two million Americans report illnesses that have been traced to foods that were eaten. And this is just the tip of the iceburg! Up to 275 million of the cases of diarhea reported annually are directly related to foods eaten.61

Cryptosporidium bacterium in the Milwaukee water supply sickened an estimated 403,000 and sent about 4,400 to the hospital.62 Another microbe, known as cyclospora, is suspected to have made more than 1,000 people sick in 11 states.63 Not a week goes by that the media does not report an outbreak of food poisoning somewhere in the United States, usually caused by salmonella, Staphylococcus aureus, or E. coli bacterium. In fact, each year hundreds of thou-sands of Americans get sick with salmonella poisoning caused by a strain that is resistant to five antibiotics!64

Symptoms of food poisoning include nausea, vomiting, and cramps. If the patient suspects food poisoning, he should begin the recommended dosage of Factor Twelve: Opti-cillin and continue for the full cycle until the vial is depleted.

For those planning to travel to a foreign country or an area of poor water quality or sanitation, the prophylactic use of Factor Twelve: Opti-cillin 5 days prior to, during, and 5 days following visiting, may be useful.

Herpes simplex HSV-1 and HSV-2

Herpes simplex is a recurrent viral infection of the skin or mucous membranes. After entering the body, the virus never leaves. it can only be kept under control so it will not break out in painful fluid-filled blisters that form around the mouth and/or genitals. Cold sores are caused by herpes simplex virus type 1 (HSV-1) while genital herpes are caused by the type 2 virus (HSV-2).

After initial infection - via direct contact with contaminated saliva, skin discharge, or sexual fluids - the sores appear two to seven days after exposure.

Recurrent eruptions are common and usually follow minor infections, trauma, emotional stress, or poor dietary habits.65

Current estimates indicate that 20 to 40 percent of the U.S. population have recurrent herpes infections.66

Not everyone exposed to HSV develops the disease. Persistent infections are seen in immunosuppressed individuals. The cell-mediated immune system is perhaps the major factor in determining the outcome of herpes exposure.

Immediately upon the onset of cold sores and/or genital blisters, the patient should begin Factor Twelve: Opti-cillin in the recommended dosage until vial has been depleted.